反应详情

2-[10-[4-(1H-imidazol-1-yl)phenoxy]decyl]-1H-isoindole-1,3(2H)-dione (Example 65) is converted to the free amino derivative by treatment with hydrazine in a refluxing ethanol solution. A portion is converted to its dihydrochloride salt by treatment with concentrated hydrochloric acid in ethanol to give the desired compound, m.p. 190°-192° C. The free base is obtained by treatment with excess 10N NaOH.