反应详情

A suspension of 2.5 g of 10-[4-(1H-imidazol-1-yl)phenoxy]decaneamine (Example 66) in 250 ml of diethyl ether containing 3 ml of triethylamine is stirred while 2.0 g of 2-naphthalenesulfonylchloride is added. The reaction mixture is stirred at room temperature for 72 hours and 50 ml of H2O added. The solvents are decanted, leaving a viscous solid. The solid is dissolved in 100 ml of 50% aqueous ethanol. Careful concentration under a gentle stream of air gives a crystalline solid. The solid is collected washed with water and dried in vacuo at room temperature; m.p. 112°-115° C.; yield, 0.2 g.

1. additionis added
2. customThe solvents are decanted
3. customleaving a viscous solid
4. concentrationCareful concentration under a gentle stream of air
5. customgives a crystalline solid
6. customThe solid is collected
7. washwashed with water
8. customdried in vacuo at room temperature
9. customyield