反应详情

温度

0 °C

Combine (4-methoxyphenyl)-hydrazine hydrochloride salt (10 g, 57 mmol), sodium hydroxide solution (50 mL, 1M), and extract with toluene. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give a residue. Combine the residue and toluene (50 mL) and cool to 0° C. Add acetaldehyde (3.5 mL, 63 mmol) dropwise as a solution in toluene (10 mL). When the addition is complete, warm to ambient temperature. After 1 hour at ambient temperature evaporate under a stream of nitrogen to give N-(4-methoxyphenyl)-N'-ethylidene hydrazine.

1. dry with materialDry the organic layer over MgSO4
2. filtrationfilter
3. customevaporate in vacuo
4. customto give a residue
5. additionWhen the addition
6. temperaturewarm to ambient temperature
7. customAfter 1 hour at ambient temperature evaporate under a stream of nitrogen