Acetaldehyde → Acetaldehyde 4-methoxyphenylhydrazone

HRID 1417414노트

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HRID 1417414 반응식
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][NH2:11])=[CH:6][CH:5]=1.[OH-].[Na+].[CH:14](=O)[CH3:15]>C1(C)C=CC=CC=1>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][N:11]=[CH:14][CH3:15])=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 177AcetaldehydeHCID 14798Sodium HydroxideHCID 27239044-Methoxyphenylhydrazine hydrochloride

생성물 1

HCID 67504694Acetaldehyde 4-methoxyphenylhydrazone

시약·촉매·용매 1

HCID 1140Toluene용매3회

반응 조건

온도
0 °C

실험 절차

Combine (4-methoxyphenyl)-hydrazine hydrochloride salt (10 g, 57 mmol), sodium hydroxide solution (50 mL, 1M), and extract with toluene. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give a residue. Combine the residue and toluene (50 mL) and cool to 0° C. Add acetaldehyde (3.5 mL, 63 mmol) dropwise as a solution in toluene (10 mL). When the addition is complete, warm to ambient temperature. After 1 hour at ambient temperature evaporate under a stream of nitrogen to give N-(4-methoxyphenyl)-N'-ethylidene hydrazine.

후처리

  1. dry with materialDry the organic layer over MgSO4
  2. filtrationfilter
  3. customevaporate in vacuo
  4. customto give a residue
  5. additionWhen the addition
  6. temperaturewarm to ambient temperature
  7. customAfter 1 hour at ambient temperature evaporate under a stream of nitrogen

출처 및 근거

ORD 기록
ord-6c909d6da00b43a8ab6e2cf5c88b3b74
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877202

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