HCID 53957871, compound → HCID 53765476, compound

HRID 1417459Notes

Reaction equation

HRID 1417459 reaction equation
[CH3:1][S:2][C:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:16][C:17]([O:19]C(C)(C)C)=[O:18]>C(O)=O>[CH3:1][S:2][C:3]1[C:15]2[NH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:16][C:17]([OH:19])=[O:18]

Participants

3

Reactant 1

HCID 53957871HCID 53957871, compound

Product 1

HCID 53765476HCID 53765476, compoundYield 104.1%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

5 ml of formic acid was added to 51 mg of tert-butyl (1-methylthiocarbazol-2-yl)acetate, as obtained in Example 2. The reaction mixture was then warmed to room temperature and stirred for 4 hours. Formic acid was next removed under reduced pressure, and the residue was recrystallized from ethyl acetate and hexane, to yield 44 mg of the title compound, melting at 210°-212° C.

Workup

  1. customas obtained in Example 2
  2. customFormic acid was next removed under reduced pressure
  3. customthe residue was recrystallized from ethyl acetate and hexane

Sources & evidence

ORD record
ord-7e6f7278335f4f888373924320f3a309
Source dataset
uspto-grants-1999_03
Patent number
US05877199

Reaction notes

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