Methanesulfonyl chloride → tert-Butyl [9-Methylsulfonyl-4-methyl-1-methylthiocarbazol-2-yl]acetate

HRID 1417496Notes

Reaction equation

[CH3:1][C:2]1[C:14]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[NH:7][C:6]=2[C:5]([S:15][CH3:16])=[C:4]([CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH:3]=1.[CH3:25][S:26](Cl)(=[O:28])=[O:27]>>[CH3:25][S:26]([N:7]1[C:6]2[C:5]([S:15][CH3:16])=[C:4]([CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH:3]=[C:2]([CH3:1])[C:14]=2[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)(=[O:28])=[O:27]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 54527372Tert-butyl (4-methyl-1-methylthiocarbazol-2-yl)acetate

Product 1

HCID 54150576tert-Butyl [9-Methylsulfonyl-4-methyl-1-methylthiocarbazol-2-yl]acetateYield 95%

Procedure

Following a procedure and using relative proportions of starting materials similar to those described in Example 4, but using tert-butyl (4-methyl-1-methylthiocarbazol-2-yl)acetate and methylsulfonyl chloride as starting materials, the title compound was obtained in a yield of 95% as an oil.

Sources & evidence

ORD record: ord-723eaf619f754264903ca522aba4d768
Source dataset: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05877199

Reaction notes

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