Hydrochloric Acid → HCID 11160421, compound

HRID 1417522Notes

Reaction equation

HRID 1417522 reaction equation
[OH:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([O-:9])=[O:8])[C@@H:3]1[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1.C[C@@H]([NH3+])C1C=CC=CC=1.Cl.CCO>O>[OH:1][C@H:2]1[CH2:6][CH2:5][C@@H:4]([C:7]([OH:9])=[O:8])[C@@H:3]1[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 131720642HCID 131720642, compound

Product 1

HCID 11160421HCID 11160421, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The salt from Step A was dissolved in water and acidified with 2N HCl and was extracted with 3 portions of EtOAc. The organic layers were washed with a portion of brine, combined, dried over sodium sulfate and evaporated to give a white solid. [α]D (EtOH)=-19.9 (c=0.675).

Workup

  1. extractionwas extracted with 3 portions of EtOAc
  2. washThe organic layers were washed with a portion of brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated
  5. customto give a white solid

Sources & evidence

ORD record
ord-fcd3bab615f3481ca45a85e96a2b7d50
Source dataset
uspto-grants-1999_03
Patent number
US05877191

Reaction notes

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