HCID 15403245, compound → HCID 15403246, compound

HRID 1417528Notes

Reaction equation

HRID 1417528 reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[CH2:27][CH2:26][C@:7]2([O:11][CH2:10][C:9]([C:12]3[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=3[C:22]([F:25])([F:24])[F:23])=[CH:8]2)[C@@H:6]1[C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)=[O:4]>C(O)(=O)C>[CH3:1][O:2][C:3]([C@H:5]1[CH2:27][CH2:26][C@:7]2([O:11][CH2:10][C@H:9]([C:12]3[CH:17]=[C:16]([C:18]([F:19])([F:20])[F:21])[CH:15]=[CH:14][C:13]=3[C:22]([F:25])([F:23])[F:24])[CH2:8]2)[C@@H:6]1[C:28]1[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=1)=[O:4]

Participants

3

Reactant 1

HCID 15403245HCID 15403245, compound

Product 1

HCID 15403246HCID 15403246, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared by the procedure given in Example 6, Step G, employing (5R,6S,7S)-6-(4-fluorophenyl)-3-(2,5-bis-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]non-3-ene-7-carboxylic acid methyl ester in place of methyl[5-(RS),6-(SR),7-(SR)]-6-(4-fluorophenyl)-3-(2-methoxy-5-((5-trifluoromethyl)tetrazol-1-yl)phenyl)-1-oxaspiro[4.4]non-3-ene-7-carboxylate, except that acetic acid was not used as a cosolvent and the reaction time was extended to between 2 and 16 hr. MS (NH3 /CI): m/e=491 (M+1).

Workup

  1. waitthe reaction time was extended to between 2 and 16 hr

Sources & evidence

ORD record
ord-744e79bbf179437ba960b347140d7a25
Source dataset
uspto-grants-1999_03
Patent number
US05877191

Reaction notes

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