HCID 15403245, compound → HCID 15403246, compound

Participants

Reaction Steps

The title compound was prepared by the procedure given in Example 6, Step G, employing (5R,6S,7S)-6-(4-fluorophenyl)-3-(2,5-bis-(trifluoromethyl)phenyl)-1-oxaspiro[4.4]non-3-ene-7-carboxylic acid methyl ester in place of methyl[5-(RS),6-(SR),7-(SR)]-6-(4-fluorophenyl)-3-(2-methoxy-5-((5-trifluoromethyl)tetrazol-1-yl)phenyl)-1-oxaspiro[4.4]non-3-ene-7-carboxylate, except that acetic acid was not used as a cosolvent and the reaction time was extended to between 2 and 16 hr. MS (NH3 /CI): m/e=491 (M+1).

Provenance & Evidence