反应详情

A solution of the free amine dissolved in methanol was treated with 1.0M HCl in ethyl ether. Removal of the solvent under under reduced pressure yielded the title compound. 1NMR (400 MHz, CD3OD): δ7.45 (dd, 2H, J=9, 6 Hz ), 7.29 (d, 1H, J=1 Hz ), 7.21 (d, 1H, J=1 Hz ), 7.19 (dd, 1H, J=9, 2 Hz ), 7.02 (t, 2H, J=9 Hz ), 7.00 (d, 1H, J=9 Hz ), 6.58 (d, 1H, J=2 Hz ), 4.10-4.02 (m, 2H), 3.85-3.75 (m, 1H), 3.79 (s, 3H), 3.13 (d, 1H, J=10 Hz ), 3.06 (t, 1H, J=9 Hz ), 2.54 (s, 3H), 2.54-2.43 (m, 1H), 2.29 (dd, 1H, J=13, 8 Hz), 2.28-2.20 (m, 1H), 2.07 (ddd, 1H, J=13, 10, 9 Hz ), 1.92 (dd, 1H, J=13, 10 Hz ), 1.90-1.80 (m, 1H).

1. customRemoval of the solvent under under reduced pressure