反应详情

To a solution of the above Compound (29b) (439 mg, 0.87 mmol) in dioxane (15 ml) was added 0.15 ml of 0.1N HCl, and the mixture stirred at room temperature for 2 hours. Water was added to the reaction, and extracted with ethyl acetate. The extract was washed with 5% sodium carbonate aqueous solution and saturated brine, and dried over anhydrous sodium sulfate. After concentration under reduced pressure, the residue was purified by a silica gel column chromatography (silica gel 15 g; toluene:ethyl acetate=1:2) to give 276 mg (62%) of Compound (29a).

1. extractionextracted with ethyl acetate
2. washThe extract was washed with 5% sodium carbonate aqueous solution and saturated brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationAfter concentration under reduced pressure
5. customthe residue was purified by a silica gel column chromatography (silica gel 15 g; toluene:ethyl acetate=1:2)