反应详情

To the above Compound (60) (265 mg, 0.40 mmol) was added 2.0 ml of 4N HCl/dioxane solution, and the mixture stirred for one hour at room temperature. The reaction mixture was made basic with 7% aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract was concentrated under reduced pressure. The residue was purified by a silica gel column chromatography (silica gel 10 g; ethyl acetate:methanol=97:3) to give 224 mg (100%) of Compound (61).

1. extractionextracted with ethyl acetate
2. concentrationThe extract was concentrated under reduced pressure
3. customThe residue was purified by a silica gel column chromatography (silica gel 10 g; ethyl acetate:methanol=97:3)