反应详情

2-[3-(3-Chloro-4-methylphenyl)-thioureido]-acetamide was prepared by the procedure described Example 11 using 18.36 g of 3-chloro-4-methylphenyl-isothiocyanate, 11.05 g of glycinamide hydrochloride, 10.1 g of triethyl amine, and 300 mL of chloroform. 22.0 Grams of the desired product was obtained, m.p. 167°-169° C. (dec.). Mass spectrum (EI, M.+) m/z 257/259. 1H-NMR (DMSO-d6 ; 400 MHz) δ9.93 (s, 1 H), 7.80 (t, 1 H), 7.73 (s, 1 H), 7.52 (s, 1 H), 7.25 (m, 2 H), 7.16 (s, 1 H), 4.07 (d, 2 H), and 2.27 ppm (s, 3 H).