HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(4-Chloro-2-methylphenyl)-2-ethylsulfanyl-3,5-dihydroimidazol-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Chloro-6-isothiocyanatotoluene | HCID 90021 | — |
| Reactant | Glycinamide hydrochloride | HCID 2723639 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(4-Chloro-2-methylphenyl)-2-ethylsulfanyl-3,5-dihydroimidazol-4-one | HCID 44295776 | — |
| Product | 2-[3-(4-Chloro-2-methylphenyl)-thioureido]-acetamide | HCID 53656054 | — |
Reaction Steps
2-[3-(4-Chloro-2-methylphenyl)-thioureido]-acetamide was prepared by the procedure described in Example 11 using 18.36 g of 4-chloro-2-methylphenyl-isothiocyanate, 11.05 g of glycinamide hydrochloride, 10.1 g of triethyl amine, and 300 mL of chloroform. 21.4 Grams of the desired compound was obtained, m.p. 170°-172° C. (dec.). Mass spectrum (EI, M.+) m/z 257/259. 1H-NMR (DMSO-d6 ; 400 MHz) δ9.38 (s, 1 H), 7.62 (broad s, 1 H), 7.45 (s, 1 H), 7.35 (d, 1 H), 7.32 (d, 1 H), 7.21 (m, 1 H), 7.12 (s, 1 H), 4.06 (d, 2 H), and 2.17 ppm (s, 3 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05877324 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-9be35a66348241cea7d132a194e7b8ac |
| Source note | uspto-grants-1999_03 |