反应详情

2-[3-(4-Chloro-2-methylphenyl)-thioureido]-acetamide was prepared by the procedure described in Example 11 using 18.36 g of 4-chloro-2-methylphenyl-isothiocyanate, 11.05 g of glycinamide hydrochloride, 10.1 g of triethyl amine, and 300 mL of chloroform. 21.4 Grams of the desired compound was obtained, m.p. 170°-172° C. (dec.). Mass spectrum (EI, M.+) m/z 257/259. 1H-NMR (DMSO-d6 ; 400 MHz) δ9.38 (s, 1 H), 7.62 (broad s, 1 H), 7.45 (s, 1 H), 7.35 (d, 1 H), 7.32 (d, 1 H), 7.21 (m, 1 H), 7.12 (s, 1 H), 4.06 (d, 2 H), and 2.17 ppm (s, 3 H).