Potassium Carbonate → HCID 54429803, compound

HRID 1417934Notes

Reaction equation

HRID 1417934 reaction equation
FC(F)(F)S([O:6][C:7]1[CH:24]=[CH:23][C:22]2[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16]([C:25](=[O:34])[NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:15][CH2:14]4)[CH2:11][CH2:10][C:9]=2[CH:8]=1)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:6][C:7]1[CH:24]=[CH:23][C:22]2[C@@H:21]3[C@H:12]([C@H:13]4[C@@:17]([CH2:19][CH2:20]3)([CH3:18])[C:16]([C:25](=[O:34])[NH:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:15][CH2:14]4)[CH2:11][CH2:10][C:9]=2[CH:8]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 86753849HCID 86753849, compound

Product 1

HCID 54429803HCID 54429803, compoundYield 87.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

About 2.05 g of compound 3a (m=6) was dissolved in a mixture of methanol (90 ml) and water (10 ml). About 1.6 g of solid potassium carbonate (K2CO3) was added and the reaction mixture was refluxed for 2.5 h. After removal of most of the methanol, 50 ml of 1N HCl was added to the reaction mixture. The precipitate formed was filtered and washed with water, yielding the phenol 4a (1.34 g, 87%).

Workup

  1. temperaturethe reaction mixture was refluxed for 2.5 h
  2. customAfter removal of most of the methanol, 50 ml of 1N HCl
  3. additionwas added to the reaction mixture
  4. customThe precipitate formed
  5. filtrationwas filtered
  6. washwashed with water

Sources & evidence

ORD record
ord-91c9de8d8c7f407894b71e6e32c7eddf
Source dataset
uspto-grants-1999_03
Patent number
US05880115

Reaction notes

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