Piperazine → HCID 54169151, compound

HRID 1417952Notes

Reaction equation

HRID 1417952 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[C:7]([P:17](=[O:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])([P:9](=[O:16])([O:13][CH2:14][CH3:15])[O:10][CH2:11][CH3:12])=[CH2:8]>>[N:1]1([CH2:8][CH:7]([P:9]([O:13][CH2:14][CH3:15])(=[O:16])[O:10][CH2:11][CH3:12])[P:17]([O:18][CH2:19][CH3:20])(=[O:24])[O:21][CH2:22][CH3:23])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 11022954Tetraethyl vinylidene phosphonate

Product 1

HCID 54169151HCID 54169151, compound

Procedure

Reaction of piperazine with tetraethyl ethenylidenebisphosphonate according to the procedure described in Example 1, above, gives tetraethyl 2-(1-piperazyl)-1,1-ethanediphosphonate. Reaction of the latter with 9-chloro-10-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benz-oxazine-6-carboxylic acid yields the title compound.

Sources & evidence

ORD record
ord-760ce2e638de4e7eaf734ade293e1e85
Source dataset
uspto-grants-1999_03
Patent number
US05880111

Reaction notes

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