反应详情

404.5 mg of 5-benzyloxy-4-methoxymethyl-9H-pyrido[3,4-b]indole-3-carboxylic acid-(1-methylethyl)-ester (1 mmol) is dissolved in 15 ml of dimethylformamide and mixed with 217 mg (1.1 mmol) of cinnamyl bromide and 358 mg (1.1 mmol) of cesium carbonate. It is stirred for 48 hours at room temperature, the reaction mixture is worked up, as described in Example 26, and after chromatography, 210 mg of 5-benzyloxy-4-methoxymethyl-9-cinnamoyl-9H-pyrido[3,4-b]indole-3-carboxylic acid-(1-methylethyl)-ester is obtained.