HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyaniline → 4-(3'-Chloro-4'-fluoroanilino)-6-(3'-methoxyanilino)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Reactant | 4-(3-Chloro-4-fluorophenylamino)-6-chloropyrimidine | HCID 54258656 | — |
| Product | 4-(3'-Chloro-4'-fluoroanilino)-6-(3'-methoxyanilino)pyrimidine | HCID 54094521 | 16% |
Reaction Steps
Using an analogous reaction procedure to that described in Example 6, 6-chloro-4-(3'-chloro-4'-fluoroanilino)pyrimidine was reacted with 3-methoxyaniline. The reaction product was recrystallised from a mixture of methylene chloride, methanol and hexane, to give 4-(3'-chloro-4'-fluoroanilino)-6-(3'-methoxyanilino)pyrimidine in 16% yield, m.p. 214°-216° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05880130 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-5f90283d9dc841738c41bd1fb2978199 |
| Source note | uspto-grants-1999_03 |