2-(4-Aminophenoxy)acetonitrile → HCID 54500648, compound

HRID 1417983Notes

Reaction equation

HRID 1417983 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[C:16]([CH2:18][O:19][C:20]1[CH:26]=[CH:25][C:23]([NH2:24])=[CH:22][CH:21]=1)#[N:17]>>[C:16]([CH2:18][O:19][C:20]1[CH:26]=[CH:25][C:23]([NH:24][C:2]2[CH:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:22][CH:21]=1)#[N:17]

Participants

3

Reactant 2

HCID 24549622-(4-Aminophenoxy)acetonitrileHCID 51046229HCID 51046229, compound

Product 1

HCID 54500648HCID 54500648, compoundYield 24%

Procedure

Using an analogous reaction procedure to that described in Example 6, 4-chloro-6-(3'-methylanilino)pyrimidine (1.0 g) was reacted with 4-cyanomethoxyaniline (0.6 g). The reaction product was chromatographed on silica to give 4-(4'-cyanomethoxyanilino)-6-(3'-methylanilino)pyrimidine in 24% yield, m.p. 207°-210° C.;

Workup

  1. customan analogous reaction procedure to
  2. customThe reaction product was chromatographed on silica

Sources & evidence

ORD record
ord-1074dc8eb10f425abffcb79c84c081cf
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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