2-(4-Aminophenoxy)acetonitrile → HCID 54500648, compound

Participants

Reaction Steps

Using an analogous reaction procedure to that described in Example 6, 4-chloro-6-(3'-methylanilino)pyrimidine (1.0 g) was reacted with 4-cyanomethoxyaniline (0.6 g). The reaction product was chromatographed on silica to give 4-(4'-cyanomethoxyanilino)-6-(3'-methylanilino)pyrimidine in 24% yield, m.p. 207°-210° C.;

Provenance & Evidence