3-(4-aminophenoxy)propan-1-ol → HCID 70187799, compound

HRID 1417988Notes

Reaction equation

HRID 1417988 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[OH:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][CH:22]=1>>[OH:16][CH2:17][CH2:18][CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:2]2[CH:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 135283923-(4-aminophenoxy)propan-1-olHCID 51046229HCID 51046229, compound

Product 1

HCID 70187799HCID 70187799, compoundYield 18%

Procedure

Using an analogous reaction procedure to that described in Example 6, 4-chloro-6-(3'-methylanilino)pyrimidine (1.35 g) was reacted with 4-(3-hydroxypropoxy)aniline.(1.0 g). The product so obtained was chromatographed on silica and triturated under methylene chloride to give 4-[4'-(3-hydrox-ypropoxy)anilino]6-(3'-methylanilino)pyrimidine in 18% yield, m.p. 196°-200° C.;

Workup

  1. customan analogous reaction procedure to
  2. customThe product so obtained
  3. customwas chromatographed on silica
  4. customtriturated under methylene chloride

Sources & evidence

ORD record
ord-4685cce7d7c64e3ca74bbe3f7c6ee7a9
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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