反应详情

Using an analogous reaction procedure to that described in Example 23, 4-(4'-hydroxyanilino)-6-(3'-methylanilino)pyrimidine (0.6 g) was reacted with 3-dimethylaminopropyl chloride. The product so obtained was chromatographed on silica and precipitated from a mixture of methylene chloride, methanol and hexane to give 4-[4'-(3-dimethylaminopropoxy)anilino]6-(3'-methylanilino)pyrimidine in 13% yield, m.p. 204°-207° C.;

1. customan analogous reaction procedure to
2. customThe product so obtained
3. customwas chromatographed on silica
4. customprecipitated from a mixture of methylene chloride, methanol and hexane