Ammonia → HCID 70187550, compound

HRID 1417994Notes

Reaction equation

HRID 1417994 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][CH:28]=1)[NH:5][C:6]1[N:11]=[CH:10][N:9]=[C:8]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH2:20][C:21](OCC)=[O:22])[CH:14]=2)[CH:7]=1.[NH3:29]>>[C:21]([CH2:20][O:19][C:15]1[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=1)[NH:12][C:8]1[CH:7]=[C:6]([NH:5][C:4]2[CH:26]=[CH:27][CH:28]=[C:2]([CH3:1])[CH:3]=2)[N:11]=[CH:10][N:9]=1)(=[O:22])[NH2:29]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 70187500HCID 70187500, compound

Product 1

HCID 70187550HCID 70187550, compoundYield 81%

Procedure

Using an analogous procedure to that described in Example 25, 6-(3'-methylanilino)-4-[3'-(ethoxycarbonylmethoxy)anilino]pyrimidine was reacted with saturated methanolic ammonia to give 4-[3'-(carbamoylmethoxy)anilino]6-(3'-methylanilino)pyrimidine in 81% yield, m.p. 192°-194° C.;

Sources & evidence

ORD record
ord-f61122786bdc4d7681a5a08b8505a3c0
Source dataset
uspto-grants-1999_03
Patent number
US05880130

Reaction notes

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