反应详情

A mixture of 4-[4'-(2,3-epoxypropoxy)anilino]6-(3'-methylanilino) pyrimidine (0.35 g), 33% dimethylamine in ethanol (10 ml) and DMF (5 ml) was stirred at room temperature for 4 hours. The mixture was poured into water, extracted with ethyl acetate and the organic phase evaporated. The residue was recrystallised from a mixture of methylene chloride, methanol and hexane to give 4-[4'-(3-dimethylamino-2-hydroxypropoxy)anilino]6-(3'-methylanilino) pyrimidine in 54% yield, m.p. 192°-195° C.;

1. extractionextracted with ethyl acetate
2. customthe organic phase evaporated
3. customThe residue was recrystallised from a mixture of methylene chloride, methanol and hexane