反应详情

A mixture of 4-[3'-hydroxyanilino]6-(3'-methylanilino)pyrimidine (1 g), 1-bromo-2,3-epoxypropane (0.44 ml) and potassium carbonate (0.95 g) in DMSO (12 ml) was stirred at ambient temperature overnight. The reaction mixture was diluted with water and extracted with methylene chloride. The organic layer was washed with water, dried (MgSO4) and evaporated to give 4-[3'-(2,3-epoxypropoxy)anilino]6-(3'-methylanilino)pyrimidine in 38% yield, m.p. 143°-145° C.;

1. extractionextracted with methylene chloride
2. washThe organic layer was washed with water
3. dry with materialdried (MgSO4)
4. customevaporated