Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 21831496 | HCID 21831496 | — |
| Reactant | HCID 88281112 | HCID 88281112 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21831587 | HCID 21831587 | — |
Reaction Steps
Preparation of 3-sulfonylamino-N-methylaminothiocarbonyl-4-methoxyphenylacetic acid ##STR18## 5 g of 3-sulfonylamino-4-methoxyphenylacetic acid were dissolved in 3 ml of DMF and stirred at 40° C. for 30 minutes with 245 mg of sodium hydroxide. 328 mg of methyl isothiocyanate were added thereto and the mixture was stirred for a further 2 h at 70° C. 2N hydrochloric acid was added to the cooled solution and the product was filtered off with suction. M.p. 174° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05880155 |
|---|
| Source dataset | uspto-grants-1999_03 |
|---|
| ORD ID | ord-4286ca65fd9f4393806d9a8355cb49ca |
|---|
| Source note | uspto-grants-1999_03 |
|---|
