Hydrochloric Acid → HCID 21831587, compound

HRID 1418049Notes

Reaction equation

HRID 1418049 reaction equation
[S:1](=[N:4][C:5]1[CH:6]=[C:7]([CH:13](C(NC)=S)[C:14]([OH:16])=[O:15])[CH:8]=[CH:9][C:10]=1[O:11][CH3:12])(=[O:3])=[O:2].S(=N[C:25]1C=C(CC(O)=O)C=CC=1OC)(=O)=O.[OH-].[Na+].CN=C=S.Cl>CN(C=O)C>[S:1](=[N:4][C:5]1[CH:6]=[C:7]([CH2:13][C:14]([OH:16])=[O:15])[CH:8]=[CH:9][C:10]=1[O:11][CH2:12][CH3:25])(=[O:3])=[O:2]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 11167Methyl isothiocyanateHCID 14798Sodium HydroxideHCID 21831496HCID 21831496, compoundHCID 88281112HCID 88281112, compound

Product 1

HCID 21831587HCID 21831587, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

Preparation of 3-sulfonylamino-N-methylaminothiocarbonyl-4-methoxyphenylacetic acid ##STR18## 5 g of 3-sulfonylamino-4-methoxyphenylacetic acid were dissolved in 3 ml of DMF and stirred at 40° C. for 30 minutes with 245 mg of sodium hydroxide. 328 mg of methyl isothiocyanate were added thereto and the mixture was stirred for a further 2 h at 70° C. 2N hydrochloric acid was added to the cooled solution and the product was filtered off with suction. M.p. 174° C.

Workup

  1. filtrationthe product was filtered off with suction

Sources & evidence

ORD record
ord-4286ca65fd9f4393806d9a8355cb49ca
Source dataset
uspto-grants-1999_03
Patent number
US05880155

Reaction notes

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