Aluminium lithium hydride → HCID 54117673, compound

HRID 1418059Notes

Reaction equation

HRID 1418059 reaction equation
[CH:1]1([CH:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH3:20])=[CH:14][CH:13]=2)[CH:5]=[C:6]([F:11])[C:7](OC)=[O:8])[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH:1]1([CH:4]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH3:20])=[CH:14][CH:13]=2)[CH:5]=[C:6]([F:11])[CH2:7][OH:8])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 53943104HCID 53943104, compound

Product 1

HCID 54117673HCID 54117673, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The method of Example 6 was repeated using methyl 4-cyclopropyl-4-(4-ethoxyphenyl)-2-fluorobut-2-enoate (Example 2) (1.2 g), diethyl ether (40 ml) and lithium aluminium hydride (0.2 g) to yield the title compound (1.05 g, 99%).

Sources & evidence

ORD record
ord-d682d37897b9439da777ac8cd88ad4ab
Source dataset
uspto-grants-1999_03
Patent number
US05880162

Reaction notes

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