Aluminium lithium hydride → HCID 53811159, compound

HRID 1418062Notes

Reaction equation

HRID 1418062 reaction equation
[F:1][C:2](=[CH:7][C:8]([CH3:21])([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:20])([F:19])[F:18])=[CH:12][CH:11]=1)[CH3:9])[C:3](OC)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[F:1][C:2](=[CH:7][C:8]([CH3:21])([C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([F:18])([F:19])[F:20])=[CH:12][CH:11]=1)[CH3:9])[CH2:3][OH:4]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 53652126HCID 53652126, compound

Product 1

HCID 53811159HCID 53811159, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The method of Example 6 was repeated using methyl 2-fluoro-4-methyl-4-(4-trifluoromethoxyphenyl)pent-2-enoate (Example 5) (0.19 g), diethyl ether (10 ml) and lithium aluminium hydride (90 mg) to yield the title compound (0.16 g, 93%).

Sources & evidence

ORD record
ord-db7bb7dac7a94541a8e5fbed271e0e0c
Source dataset
uspto-grants-1999_03
Patent number
US05880162

Reaction notes

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