Benzene → HCID 53684786, compound

HRID 1418064Notes

Reaction equation

HRID 1418064 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH:5]1([CH:8]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=2)[CH:9]=[C:10]([F:13])[CH2:11][OH:12])[CH2:7][CH2:6]1.C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:12][CH2:11][C:10]([F:13])=[CH:9][CH:8]([CH:5]1[CH2:6][CH2:7]1)[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH3:22])=[CH:16][CH:15]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 54117673HCID 54117673, compound

Product 1

HCID 53684786HCID 53684786, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 11 was repeated using acetyl chloride (1.2 ml), 4-cyclopropyl-4-(4-ethoxyphenyl)-2-fluorobut-2-enol (Example 7) (0.65 g), benzene (34 ml) and pyridine (0.24 ml) to yield the title compound (0.75 g, 99%).

Sources & evidence

ORD record
ord-8deab34530924548939888fac036b0e8
Source dataset
uspto-grants-1999_03
Patent number
US05880162

Reaction notes

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