Benzene → 4-(4-Chlorophenyl)-2-fluoro-4-methylpent-2-enyl acetate

HRID 1418065Notes

Reaction equation

HRID 1418065 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:19])([CH3:18])[CH:13]=[C:14]([F:17])[CH2:15][OH:16])=[CH:8][CH:7]=1.C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:16][CH2:15][C:14]([F:17])=[CH:13][C:12]([C:9]1[CH:8]=[CH:7][C:6]([Cl:5])=[CH:11][CH:10]=1)([CH3:19])[CH3:18])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 537910454-(4-Chlorophenyl)-2-fluoro-4-methylpent-2-enol

Product 1

HCID 538048424-(4-Chlorophenyl)-2-fluoro-4-methylpent-2-enyl acetateYield 87%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 11 was repeated using acetyl chloride (0.76 ml), 4-(4-chlorophenyl)-2-fluoro4-methylpent-2-enol (Example 8) (0.34 g), benzene (20 ml) and pyridine (0.15 ml) to yield the title compound (0.35 g, 87%).

Sources & evidence

ORD record
ord-895d64ec99ff4364ac623ed9bbae9390
Source dataset
uspto-grants-1999_03
Patent number
US05880162

Reaction notes

Loading…