Benzene → 4-(4-Ethoxyphenyl)-2-fluoro-4-methylpent-2-enyl acetate

HRID 1418066Notes

Reaction equation

HRID 1418066 reaction equation
[Cl-].[C:2]([O-:5])(=[O:4])[CH3:3].[CH2:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:22])([CH3:21])[CH:16]=[C:17]([F:20])[CH2:18]O)=[CH:11][CH:10]=1)[CH3:7].C1C=CC=CC=1>N1C=CC=CC=1>[C:2]([O:5][CH2:18][C:17]([F:20])=[CH:16][C:15]([C:12]1[CH:11]=[CH:10][C:9]([O:8][CH2:6][CH3:7])=[CH:14][CH:13]=1)([CH3:21])[CH3:22])(=[O:4])[CH3:3]

Participants

5

Reactant 3

HCID 241BenzeneHCID 21917432Acetate chlorideHCID 536921534-(4-Ethoxyphenyl)-2-fluoro-4-methylpent-2-enol

Product 1

HCID 543050034-(4-Ethoxyphenyl)-2-fluoro-4-methylpent-2-enyl acetateYield 99%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 11 was repeated using acetate chloride (0.17 ml), 4-(4-ethoxyphenyl)-2-fluoro-4-methylpent-2-enol (Example 9) (86 mg), benzene (4 ml) and pyridine (0.04 ml) to yield the title compound (0.1 g, 99%).

Sources & evidence

ORD record
ord-6eabaceaecac46b6af189f4b22b0bdbc
Source dataset
uspto-grants-1999_03
Patent number
US05880162

Reaction notes

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