Benzene → HCID 54398959, compound

HRID 1418067Notes

Reaction equation

HRID 1418067 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6](=[CH:9][C:10]([CH3:23])([C:12]1[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=1)[CH3:11])[CH2:7][OH:8].C1C=CC=CC=1>N1C=CC=CC=1>[C:1]([O:8][CH2:7][C:6]([F:5])=[CH:9][C:10]([CH3:23])([C:12]1[CH:17]=[CH:16][C:15]([O:18][C:19]([F:20])([F:21])[F:22])=[CH:14][CH:13]=1)[CH3:11])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6367Acetyl chlorideHCID 53811159HCID 53811159, compound

Product 1

HCID 54398959HCID 54398959, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The method of Example 11 was repeated using acetyl chloride (0.41 ml), 2-fluoro-4-methyl-4-(4-trifluoromethoxyphenyl)pent-2-enol (Example 10) (0.2 g), benzene (10 ml) and pyridine (0.081 ml) to yield the title compound (0.23 g, 99%).

Sources & evidence

ORD record
ord-c7e55bdbd194499a8605f818f60b68d6
Source dataset
uspto-grants-1999_03
Patent number
US05880162

Reaction notes

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