3-Bromodiphenyl ether → 4-(4-Ethoxyphenyl)-2-fluoro-4-methyl-1-(3-phenoxyphenyl)pent-2-ene

Participants

Reaction Steps

The method of Example 16 was repeated using a Grignard reagent, prepared from 3-phenoxyphenyl bromide (0.31 g), tetrahydrofuran (2 ml) and magnesium (24 mg), and 4-(4-ethoxyphenyl)-2-fluoro-methylpent-2-enyl acetate (Example 14) (70 mg). The residue after evaporation was purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9) to give the title compound (44 mg, 45%/).

Provenance & Evidence