反应详情

The method of Example 16 was repeated using a Grignard reagent, prepared from 3-phenoxyphenyl bromide (0.31 g), tetrahydrofuran (2 ml) and magnesium (24 mg), and 4-(4-ethoxyphenyl)-2-fluoro-methylpent-2-enyl acetate (Example 14) (70 mg). The residue after evaporation was purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9) to give the title compound (44 mg, 45%/).

1. customThe residue after evaporation
2. customwas purified by preparative thin layer chromatography (solvent: diethyl ether/hexane; 1:9)