反应详情

3-bromo-2-formylthiophene (3.89 parts, 0.02M) was heated at reflux with dry ethyleneglycol (1.6 parts) toluene (25 parts) and p-toluene sulphonic acid (0.1 parts) in a vessel equipped with a Dean and Stark separator for 16 hours. The reactants were then cooled and evaporated into silica. The silica was formed into a column which was then developed by elution with hexane containing increasing amounts of dichloromethane. The product was obtained from fractions containing 10-60% dichloromethane as a pale straw-coloured oil (4.42 parts).

1. customequipped with a Dean and Stark
2. temperatureThe reactants were then cooled
3. customevaporated into silica
4. customThe silica was formed into a column which
5. washwas then developed by elution with hexane containing
6. temperatureincreasing amounts of dichloromethane
7. customThe product was obtained from fractions