Pyridine → 1-(4-Bromophenyl)-3-[4-(2-cyanoethyl)phenyl]imidazolidin-2-one

Participants

Reaction Steps

To 750 mg of 1-(4-bromophenyl)-3-[4-[2-(aminocarbonyl)-ethyl]-phenyl]-imidazolidin-2-one and 320 mg of pyridine in 10 ml of tetrahydrofuran are added dropwise at -10° C., with stirring, 460 mg of trifluoroacetic acid anhydride in 1 ml of tetrahydrofuran. After stirring overnight at ambient temperature the reaction mixture is diluted with ice water and the precipitate obtained is suction filtered, washed and dried.

Provenance & Evidence