反应详情

To 750 mg of 1-(4-bromophenyl)-3-[4-[2-(aminocarbonyl)-ethyl]-phenyl]-imidazolidin-2-one and 320 mg of pyridine in 10 ml of tetrahydrofuran are added dropwise at -10° C., with stirring, 460 mg of trifluoroacetic acid anhydride in 1 ml of tetrahydrofuran. After stirring overnight at ambient temperature the reaction mixture is diluted with ice water and the precipitate obtained is suction filtered, washed and dried.

1. stirringAfter stirring overnight at ambient temperature the reaction mixture
2. customthe precipitate obtained
3. filtrationfiltered
4. washwashed
5. customdried