Trimethylacetamide → N-[2-t-Butyl-5-(2,2-dimethylpropanoyl)aminocarbonylphenyl]-3-(2,4-dimethoxyphenyl)octanamide

HRID 1418156Notes

Reaction equation

HRID 1418156 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](O)=[O:12])=[CH:7][C:6]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:4])([CH3:3])[CH3:2].[CH3:34][C:35]([CH3:40])([CH3:39])[C:36]([NH2:38])=[O:37]>C(OCC)(=O)C>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([NH:38][C:36](=[O:37])[C:35]([CH3:40])([CH3:39])[CH3:34])=[O:12])=[CH:7][C:6]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:3])([CH3:2])[CH3:4]

Participants

4

Reactant 2

HCID 12957TrimethylacetamideHCID 19348635HCID 19348635, compound

Product 1

HCID 19348506N-[2-t-Butyl-5-(2,2-dimethylpropanoyl)aminocarbonylphenyl]-3-(2,4-dimethoxyphenyl)octanamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Following a similar procedure to that described in Example 139, but using N-(2-t-butyl-5-carboxyphenyl)-3-(2,4-dimethoxyphenyl)octanamide (prepared as described in Preparation 7) and 2,2-dimethylpropanamide, the title compound was obtained as crystals, melting at 170°-172° C. (from ethyl acetate).

Sources & evidence

ORD record
ord-38496f231d4c4bef97bb8de0cfa39e0b
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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