Methyl 3-(2,4-dimethoxy-5-propionylphenyl)octanoate → 3-(2,4-Dimethoxy-5-propionylphenyl)octanoic acid

HRID 1418207Notes

Reaction equation

HRID 1418207 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([C:11](=[O:14])[CH2:12][CH3:13])=[CH:5][C:4]=1[CH:15]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:16][C:17]([O:19]C)=[O:18]>C(OCC)(=O)C.CCCCCC>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[C:6]([C:11](=[O:14])[CH2:12][CH3:13])=[CH:5][C:4]=1[CH:15]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:16][C:17]([OH:19])=[O:18]

Participants

3

Reactant 1

HCID 19348498Methyl 3-(2,4-dimethoxy-5-propionylphenyl)octanoate

Product 1

HCID 193485563-(2,4-Dimethoxy-5-propionylphenyl)octanoic acid

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The methyl 3-(2,4-dimethoxy-5-propionylphenyl)octanoate prepared as described in step (i) above was hydrolyzed in a similar manner to that described in Preparation 7 to give the title compound as crystals, melting at 92.5°-94° C. (from ethyl acetate-hexane).

Workup

  1. customdescribed in Preparation 7

Sources & evidence

ORD record
ord-458e3daa2a7c4ba28220265aa0ea7c70
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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