3-Methoxypropyl 4-methylbenzenesulfonate → 3-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

HRID 1418219Notes

Reaction equation

HRID 1418219 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12]C)=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1.[CH3:20][O:21][CH2:22][CH2:23][CH2:24]OS(C1C=CC(C)=CC=1)(=O)=O>CCOCC>[CH3:20][O:21][CH2:22][CH2:23][CH2:24][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([OH:12])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1

Participants

4

Reactant 2

HCID 135229883-Methoxypropyl 4-methylbenzenesulfonateHCID 19348616Methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate

Product 1

HCID 193487163-[4-(3-Methoxypropoxy)-2-methoxyphenyl]heptanoic Acid

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate (prepared as described in Preparation 58A), and 3-methoxy-1-tosyloxypropane, the corresponding ether derivative was obtained. Hydrolysis of this derivative and subsequent treatment of the reaction mixture were conducted in a similar manner to that described in Preparation 7 to give the title compound as an oily substance.

Workup

  1. customthat described in Preparation 45A(i)
  2. customHydrolysis of this derivative and subsequent treatment of the reaction mixture
  3. customdescribed in Preparation 7

Sources & evidence

ORD record
ord-6675ecc54324439a8c127f99f53fcf69
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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