2-Bromoethyl ethyl ether → Methyl 3-[2-methoxy-4-(2-ethoxyethoxy)phenyl]-5-methylhexanoate

HRID 1418237Notes

Reaction equation

HRID 1418237 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1.[CH2:20]([O:22][CH2:23][CH2:24]Br)[CH3:21]>>[CH3:19][O:18][C:4]1[CH:3]=[C:2]([O:1][CH2:21][CH2:20][O:22][CH2:23][CH3:24])[CH:7]=[CH:6][C:5]=1[CH:8]([CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:9][C:10]([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 611412-Bromoethyl ethyl etherHCID 19348568Methyl 3-(4-hydroxy-2-methoxyphenyl)-5-methylhexanoate

Product 1

HCID 19348584Methyl 3-[2-methoxy-4-(2-ethoxyethoxy)phenyl]-5-methylhexanoate

Procedure

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(4-hydroxy-2-methoxyphenyl)-5-methylhexanoate (prepared as described in Preparation 58B) and 2-ethoxyethyl bromide, the title compound was obtained as an oily substance.

Workup

  1. customthat described in Preparation 45A(i)

Sources & evidence

ORD record
ord-373c3a40b647489f99ea5b1e2a41749c
Source dataset
uspto-grants-1999_03
Patent number
US05880147

Reaction notes

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