Hydrochloric Acid → HCID 18429145, compound

HRID 1418267Notes

Reaction equation

HRID 1418267 reaction equation
C([O:4][CH:5]([CH3:32])[C:6]([NH:8][C:9]1[C:10]([I:31])=[C:11]([C:17]([I:30])=[C:18]([NH:21][C:22](=[O:29])[CH:23]([O:25]C(=O)C)[CH3:24])[C:19]=1[I:20])[CH2:12]CC([O-])=O)=[O:7])(=O)C.[OH-:33].[Na+].Cl>CO.O>[OH:4][CH:5]([CH3:32])[C:6]([NH:8][C:9]1[C:10]([I:31])=[C:11]([C:17]([I:30])=[C:18]([NH:21][C:22](=[O:29])[CH:23]([OH:25])[CH3:24])[C:19]=1[I:20])[CH2:12][OH:33])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18429210HCID 18429210, compound

Product 1

HCID 18429145HCID 18429145, compoundYield 46%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

N,N'-Bis(2-acetoxypropionyl)-3,5-diamino-2,4,6-triiodobenzylacetate (0.16 g, 0.2 mmol) was dissolved in a mixture of methanol (5 ml) and water (5 ml) and the pH was adjusted to 12 using a 1M aqueous solution of NaOH. After stirring for 15 h, the solution was neutralized with 1M HCl and the solvents were removed by evaporation. Purification by preparative HPLC gave 61 mg (46%) of the pure product.

Workup

  1. customthe solvents were removed by evaporation
  2. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-92bfbd42dcc745f28111fc60cbae7d4a
Source dataset
uspto-grants-1999_03
Patent number
US05882628

Reaction notes

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