1,1'-Carbonyldiimidazole → HCID 9848132, compound

Participants

Reaction Steps

A solution of 0.8 g of 2-(1,3-benzodioxol-5-yl)-2-(4, 6-dimethyl-2,3-dihydropyridazin-3-on-2-yl)acetic acid and 0.64 g of carbonyldiimidazole in 50 ml of THF is heated at 60° for 2 hours. 0.79 g of 4-isopropylbenzenesulfonamide and 0.59 g of 1, 8-diazabicyclo[5.4.0]undec-7-ene are then added and the mixture is stirred at this temperature for a further 1 hour. After customary working up, 2-(1,3-benzodioxol-5-yl)-2-(4,6-dimethyl-2,3-dihydropyridazin-3-on-2-yl) N-(4-isopropylphenylsulfonyl)acetamide is obtained, m.p. 105°.

Provenance & Evidence