1,1'-Carbonyldiimidazole → HCID 9848132, compound

HRID 1418324Notes

Reaction equation

HRID 1418324 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([N:14]3[C:19](=[O:20])[C:18]([CH3:21])=[CH:17][C:16]([CH3:22])=[N:15]3)[C:11](O)=[O:12])=[CH:9][C:4]=2[O:3][CH2:2]1.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH:35]([C:38]1[CH:43]=[CH:42][C:41]([S:44]([NH2:47])(=[O:46])=[O:45])=[CH:40][CH:39]=1)([CH3:37])[CH3:36].N12CCCN=C1CCCCC2>C1COCC1>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]([N:14]3[C:19](=[O:20])[C:18]([CH3:21])=[CH:17][C:16]([CH3:22])=[N:15]3)[C:11]([NH:47][S:44]([C:41]3[CH:42]=[CH:43][C:38]([CH:35]([CH3:37])[CH3:36])=[CH:39][CH:40]=3)(=[O:45])=[O:46])=[O:12])=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

6

Reactant 4

HCID 682631,1'-CarbonyldiimidazoleHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 2323144-(1-Methylethyl)benzenesulfonamideHCID 15379787HCID 15379787, compound

Product 1

HCID 9848132HCID 9848132, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 0.8 g of 2-(1,3-benzodioxol-5-yl)-2-(4, 6-dimethyl-2,3-dihydropyridazin-3-on-2-yl)acetic acid and 0.64 g of carbonyldiimidazole in 50 ml of THF is heated at 60° for 2 hours. 0.79 g of 4-isopropylbenzenesulfonamide and 0.59 g of 1, 8-diazabicyclo[5.4.0]undec-7-ene are then added and the mixture is stirred at this temperature for a further 1 hour. After customary working up, 2-(1,3-benzodioxol-5-yl)-2-(4,6-dimethyl-2,3-dihydropyridazin-3-on-2-yl) N-(4-isopropylphenylsulfonyl)acetamide is obtained, m.p. 105°.

Sources & evidence

ORD record
ord-d6cc9254262843d8a2646d1f565816ee
Source dataset
uspto-grants-1999_03
Patent number
US05883090

Reaction notes

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