HCID 15428311, compound → HCID 15379550, compound

HRID 1418327Notes

Reaction equation

HRID 1418327 reaction equation
[OH:1][CH2:2][C:3]1[N:4]2[CH:10]=[N:9][CH:8]=[C:5]2[S:6][CH:7]=1>ClCCl.[O-2].[O-2].[Mn+4]>[S:6]1[CH:7]=[C:3]([CH:2]=[O:1])[N:4]2[CH:10]=[N:9][CH:8]=[C:5]12

Participants

4

Reactant 1

HCID 15428311HCID 15428311, compound

Product 1

HCID 15379550HCID 15379550, compoundYield 71%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

In 20 ml of dichloromethane was suspended 0.211 g of 3-hydroxymethylimidazo[5,1-b]thiazole. Manganese dioxide (1.1 g) was added to the suspension, and the mixture was stirred at room temperature for 16 hr. The reaction mixture was filtered, and the filtrate was evaporated to dryness under reduced pressure to give 0.146 g (yield 71%) of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-f3dfccc4e6984459b4bd698ccf4bae6f
Source dataset
uspto-grants-1999_03
Patent number
US05883089

Reaction notes

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