Diethyl Ether → HCID 57247189, compound

HRID 1418374Notes

Reaction equation

HRID 1418374 reaction equation
[CH2:1]([N:3]=[C:4]=[O:5])[CH3:2].C1O[C:9]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[O:8]C1.[CH3:16][CH2:17][O:18]CC>ClCCl>[CH2:17]1[O:18][C:4]([N:12]2[CH2:13][CH2:14][C:9](=[O:8])[CH2:10][CH2:11]2)([NH:3][CH2:1][CH3:2])[O:5][CH2:16]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 8022Ethyl isocyanateHCID 674351,4-Dioxa-8-azaspiro(4.5)decane

Product 1

HCID 57247189HCID 57247189, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

Ethyl isocyanate (0.85 ml, 0.76 g, 10.7 mmol) was added dropwise with stirring to 4-piperidone ethylene ketal (1.43 g, 10 mmol) in dry dichloromethane (30 ml). The resulting pale yellow solution was stirred at 20° C. for 24 h, then evaporated to yield a yellow solid. Trituration with ether gave the title compound as a white crystalline solid (1.85 g), m.p. 120°-122° C.

Workup

  1. customevaporated
  2. customto yield a yellow solid

Sources & evidence

ORD record
ord-b9661f140c6345b3b7b9fd3d51ec6cf0
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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