Acetonitrile → N,N-dimethyl-1-(piperidin-4-yl)-2',3'-dihydrospiro[piperidine-4,4'-quinoline]-1'-carboxamide

HRID 141838Notes

Reaction equation

HRID 141838 reaction equation
[CH3:1][N:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([CH:14]3[CH2:15][CH2:16][N:17]([C:20]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:26])[CH2:18][CH2:19]3)[CH2:12][CH2:13]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]21)[CH3:33].[CH3:44][C:45]#[N:46].[Cl:41][CH2:42][Cl:43].[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40]>>[CH3:1][N:2]([C:3](=[O:4])[N:5]1[CH2:6][CH2:7][C:8]2([CH2:9][CH2:10][N:11]([CH:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[CH2:12][CH2:13]2)[c:27]2[cH:28][cH:29][cH:30][cH:31][c:32]21)[CH3:33]

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57863245tert-butyl 4-(1'-(dimethylcarbamoyl)-2',3'-dihydro-1'H-spiro[piperidine-4,4'-quinoline]-1-yl)piperidine-1-carboxylate

Product 1

HCID 24798103N,N-dimethyl-1-(piperidin-4-yl)-2',3'-dihydrospiro[piperidine-4,4'-quinoline]-1'-carboxamide

Sources & evidence

ORD record
ord-a01d277dccf94f1c89b30fed04e8fa21
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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