反应详情

A solution of 2-aminobenzamidine dihydrochloride (Example A) (1.0 g, 4.8 mmol) and benzaldehyde (0.48 ml, 5.8 mmol) in ethanol (30 ml) was heated at reflux for 2 hours. The solution was cooled and the solvent evaporated to give an oil which was purified by flash chromatography on aluminium oxide (Brockman 1, activated neutral) using dichloromethane/methanol as eluant to give a solid which was recrystallised from isopropyl alcohol to afford the title compound as a solid (0.65 g), m.p. 212°-214° C.

1. temperatureat reflux for 2 hours
2. temperatureThe solution was cooled
3. customthe solvent evaporated
4. customto give an oil which
5. customwas purified by flash chromatography on aluminium oxide (Brockman 1, activated neutral)
6. customto give a solid which
7. customwas recrystallised from isopropyl alcohol