Ethyl 4-oxo-1-piperidinecarboxylate → HCID 136365333, compound

HRID 1418385Notes

Reaction equation

HRID 1418385 reaction equation
[ClH:1].Cl.[OH:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]([NH2:13])[C:5]=1[C:6]([NH2:8])=[NH:7].O=[C:15]1[CH2:20][CH2:19][N:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:17][CH2:16]1>>[ClH:1].[NH2:7][C:6]1[C:5]2[C:9](=[CH:10][CH:11]=[CH:12][C:4]=2[OH:3])[NH:13][C:15]2([CH2:20][CH2:19][N:18]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:17][CH2:16]2)[N:8]=1

Participants

3

Reactant 2

HCID 34767Ethyl 4-oxo-1-piperidinecarboxylateHCID 136365334HCID 136365334, compound

Product 1

HCID 136365333HCID 136365333, compound

Procedure

This was prepared by the method of Example 173 using 2-hydroxy-6-aminobenzamidine dihydrochloride (Example D) and ethyl 4-oxopiperidine-1-carboxylate to give the title compound as a yellow solid, MS (+CI) 305 ([M+H]+), 1H NMR (d6 -DMSO) 11.80 (1H, s), 9.96 (1H, s), 8.64 (1H, s), 8.54 (1H, s), 7.49 (1H, s), 7.23 (1H, t), 6.31 (1H, d), 6.27 (1H, d), 4.02-4.08 (2H, m), 3.5-3.7 (2H, m), 3.3-3.5 (2H, m), 1.6-1.8 (2H, m), 1.19 (3H, t).

Sources & evidence

ORD record
ord-083b7ddf29e94f65b1c562eb759b2622
Source dataset
uspto-grants-1999_03
Patent number
US05883102

Reaction notes

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